Fipronil: what is it, the principle of action, the basis of application and safety measures

Hello! Last year I was on a business trip on business issues. They settled me in a hostel of some local enterprise.

The conditions were not royal, but to live a couple of days is quite tolerable. But the main problem was not even that.

Already on the first night I met my neighbors - cockroaches. There was no point in starting a fight with them, I only advised the manager to use fipronil. In their situation, only he can help. To make it clearer, now I will tell you in detail about fipronil - what it is and how it works.

Fipronil

Fipronil is a widely used insecticide. Fipronil is used to combat ants, bugs, cockroaches, fleas, ticks, termites, moths, crickets, thrips, weevils and other insects. Fipronil is a white powder with a smell of mold. Fipronil was first registered for use in the United States in 1996.

Fipronil is a wide spectrum insecticide. Fipronil kills insects when they eat or come into contact with it. Fipronil works by disrupting the normal functioning of the central nervous system in insects.

Fipronil is a slow acting poison. After consuming the bait mixed with fipronil, the poisoned insect returns to the colony or nest. Insect residues may contain a sufficient dose of residual pesticide to kill other insects in the colony.

In ants, the exchange of bait among members of the colony contributes to the spread of poison throughout the colony. According to the principle of cascade effect, about 95% of ants and cockroaches are destroyed within 3 days.

Fipronil is highly toxic to fish and aquatic invertebrates. Its tendency to bind to sediments and its low solubility in water can reduce the potential danger to wildlife in the aquatic environment.

Fipronil is also used as an active ingredient in flea control products in pets, in pest control in corn fields, golf courses and commercial turf.

The health effects of short-term exposure to fipronil depend on how the subject was exposed to the chemical. Direct, short-term skin contact can result in mild skin irritation.

When fipronil was ingested orally, sweating, nausea, vomiting, headache, abdominal pain, dizziness, weakness, and cramps were observed. Signs and symptoms from short-term exposure to fipronil generally disappear without special treatment.

The soil quickly decomposes. The main decomposition products in soil under aerobic conditions are sulfone and amide. Fipronil residues, even when granules are introduced into the soil, extend to a depth of not more than 30 cm.

What you need to pay attention when using the drug

Fipronil is a chemical. the active substance of pesticides (phenylpyrazole), used in rural households., in honey. and household processing, veterinary pest control.

In its pure form, it is a transparent crystallized powder with a mold smell. Does not respond to thermal effects. Able to decompose slowly under the influence of light.

How it affects parasites

Fipronil refers to drugs with a wide spectrum of action - contact and intestinal poison. It has moderate systemic properties and high residual activity when processing leaves. They can process the seed.

Due to the peculiarities of mechanical action, this substance can actively fight many types of insects that are resistant to other toxic compounds.

The insect dies from paralysis within 8-10 hours after exposure to an insecticide. The drug acts as a “protector" for two weeks.

Addictive. The presence of resistance to the substance in various types of insects suggests that it cannot be used on an ongoing basis.

Application Features:

This poison is recommended to be used alternately with other insecticides. It can also be used as food lures.

Used in agriculture against parasites in the cultivation of the following crops for destruction:

• wheat (ground beetle, bug, larvae);
• barley (drunkard);
• potatoes (count beetle);
• plots, pastures (locusts).

Effectively against orthopterans, coleopterans and parenting insects.

Fipronil treats vegetative parts of plants and soil. The drug is highly toxic.

Abroad, the drug is used to destroy leaf-living and insects living in the soil. A successful result in the fight against locusts (migratory and desert) was noted. It is the main drug used in locust persecution.

The drug is also used in medicine and in the household for bullying pests:

1. synanthropic cockroaches;
2. ants.

Due to the fact that the product has a high level of toxicity to warm-blooded animals, its use in the form of bait stations or gels is allowed during pest control. Due to the systemic actions of the substance, they are also poisoned by ticks and fleas.

Toxicological characteristics

The tool refers to phenylpyrazoles that have long-term insecticidal toxicity. It is absorbed by plants from the soil and seeds. Since it decomposes very slowly under the influence of sunlight, it acts for a very long time after processing.

It moves on the soil very slowly, to a depth of up to 30 cm. One of the most important properties of the drug is resistance to rain. According to some reports, the product can be retained on the leaves while maintaining its activity by 75%, even if the rain has passed half an hour after spraying.

Poisonous action

Toxic to rats, for rabbits acts dermally. It does not irritate the skin, but is a mild irritant to the eyes.

In animals, it is slowly metabolized, but the substance itself can be detected even a week after the treatment.

Symptoms of poisoning

Acute poisoning can manifest itself in severe irritation, lethargy and convulsions. After the drug stops its action, all symptoms disappear.

Fipronil is prohibited to use:

It is forbidden to apply auricularly for ear scabies or eardrum defects.

What you need to pay attention when using fipronil:

Personal prevention

When working with this substance, it is recommended to observe the rules of personal hygiene and safety:

• when working with poisons you must not smoke, eat or drink;
• after finishing work, wash your hands with warm soapy water;
• during the day after treatment, the animal can not be touched, you need to protect small children from him.

https://dezplan.ru/deystvuyushchee-veshchestvo/fipronil

Active ingredients of agricultural insecticides and acaricides (Fipronil)

1. Synonyms - Fipronil, Regent, Cosmos, Adonis
2. In English - Fipronil
3. Chemical formula - C12H4Cl2F6N4OS
4. Chemical Class - Phenylpyrazoles
5. Formulation - 80% Water-dispersible granules, 4% Emulsion Concentrate
6. Route of entry - Intestinal pesticide, contact pesticide, systemic pesticide
7. Organism Effects - Pesticide, Insecticide
8. Methods of application - Spraying
9. CAS Number - 120068-37-3

Fipronil [5-amino- [2,6-dichloro-4- (trifluoromethyl) phenyl] -4 - [(1R, S) - (trifluoromethyl) sulfinyl] -1H-pyrazole-3-carbonitrile] - chemical active substance of pesticides ( class of phenylpyrazoles), is used in agriculture and in the practice of medical, sanitary and household pest control to combat harmful and synanthropic insects, as well as in veterinary medicine.

Physical and chemical properties

In its pure form, it is a colorless crystalline powder with a moldy odor. It is thermally stable, in the presence of metals it is not destroyed, at pH 5-7 it does not hydrolyze, it is stable; at pH = 9 it hydrolyzes in 28 days by 50%. Slowly decomposes in sunlight.

Physical characteristics:

Pests

Fipronil is a contact and intestinal insecticide with a wide spectrum of action, has moderate systemic properties and good residual activity when processing leaves, and can be used for seed treatment and dressing.

The mechanism of action of fipronil is to block gamma-aminobutyric acid (GABA), which regulates the passage of a nerve impulse through the chlorion channels in the membranes of nerve cells, which violates the functions of the nervous system. GABA in the system of transmission of excitation through nerve cells, like acetylcholine, plays the role of a mediator.

It has a high degree of affinity for [3H] -4-phenyl-4-n-propylbicycloorthobenzoate, which ensures the selectivity of fipronil on insects. The death of insects occurs from paralysis 8 hours after the insecticide enters the body of the insect as a result of overexcitation of the central nervous system.

The protective effect of fipronil-based drugs is about 14 days.

Resistance The presence of tolerance to fipronil in different populations and races of insects suggests that it should not be used for a long time, this insecticide is an excellent component of insecticide alternation schemes, including when used in the form of food lures.

Fipronil Pesticides

For agriculture:

1. Adonis, CE (registration deadline)
2. Monarch, WDG
3. Regent, VDG

For medical, sanitary and domestic use:

Application

In agriculture. The active substance is effective against pests from orders of orthopterans and beetles, as well as soil-borne pests. Actively as a soil insecticide and for the treatment of the vegetative part of plants. However, the extent of use of this compound is limited by high toxicity.

Fipronil-based preparations are approved for use against wheat pests (ground beetle, bug bug (larvae of young ages, leech), barley (lemma), potatoes (Colorado potato beetle), pastures, areas inhabited by locusts, wild vegetation (locusts).

Abroad. Fipronil, according to foreign press, is used to control both leafy and soil insects.

It was successfully used in the fight against desert and migratory locusts (4.8–11 grams of active ingredient per hectare), and in 2003, the FAO (Food and Agriculture Organization of the United Nations) included it as the main preparation for controlling desert locusts.

For the purposes of medical, sanitary and household disinsection, fipronil-based preparations are used to destroy synanthropic cockroaches and ants at objects of various categories: residential, industrial, medical and preventive, children's, food.

Due to its systemic effect, preparations based on the active substance are also used in veterinary medicine against fleas and ticks.

Instructions for use

According to common practice, instructions for the use of a substance are developed in relation to preparations containing this substance. In order to read the instructions for the drug, you must go to the page of this insecticide (presented on the right).

Toxicological data table compiled in accordance with GN 1.2.2701-10.

Toxicological properties and characteristics

Fipronil belongs to the group of phenylpyrazoles, characterized by high long-term insecticidal toxicity. May be absorbed by plants from soil and seeds. Due to the slow decomposition in sunlight, a long-lasting effect is achieved after spraying. In plants, soil, and water, the compound is oxidized to fipronil sulfone.

Metabolites formed in the environment: sulfide, sulfone and sulforide also have an insecticidal effect.

An important property of preparations based on fipronil is their resistance to washing off by rain. Tests conducted in the Ipatovsky district of the Stavropol Territory showed that the Regent preparation was kept on the leaves and remained effective at the level of 75% even if it rained 40 minutes after treatment.

Toxic effect. LD50 for rats 97 mg / kg; LD50 dermal for rabbits> 2000 mg / kg. Does not irritate the skin, slightly irritates the eyes. In animals, it is gradually metabolized, but the labeled active substance is also detected 7 days after treatment.

Hazard classes. Fipronil-based drugs belong to the first and third hazard classes for bees and to the second, third hazard classes for humans.

Receipt history

Fipronil was synthesized in 1987. In Russia, fipronil-based drugs have been tested since 1995. It was tested in 1995 in the area of ​​Lake Baikal against a locust complex, including 10 species of Gomphocerinae. Fipronil caused 81-87% death of the orthoptera after 24 hours.

In 1993, on the basis of fipronil, the first commercial drug for medical disinfestation appeared - Goliath gel (poisoned bait).

FIPRONIL for animals

International Nonproprietary Name (INN): BAN accepted in the UK.

Included in the following preparations for animals:

• BLOCHNET DROPS - solution for external use, reg. No: PVR-2-5.6 / 01768 dated 12/11/2006, NVP ASTRAFARM LLC (Russia) - produced by NPK SKiFF LLC (Russia)
• IN-AP COMPLEX - solution for external use, reg. No: PVR-2-2.0 / 02530 dated 04/15/2010, NVP ASTRAFARM LLC (Russia), manufactured by NPK SKiFF LLC (Russia)
• FIPRIST® SPOT OH - solution for external use, reg. No .: 705-3-14.15-3012 No. PVI-3-8.0 / 03272 dated 02.19.2016, KRKA d.d., Novo Mesto (Slovenia)
• AMIT FORTE - solution for external use, reg. No: PVR-2-5.8 / 02197 dated 08/30/2008, Agrovetzashchita NVC LLC (Russia), manufactured by: AVZ S-P LLC (Russia)
• DROPS INSECTOACARICIDAL BARS® FORTE - solution for external use, reg. No: PVR-2-7.7 / 02043 dated 11/26/2007, Agrovetzashchita NVC LLC (Russia), manufactured by: AVZ S-P LLC (Russia)
• SPRAY INSECTOACARICIDAL BARS® FORTE - solution for external use, reg. No: PVR-2-7.7 / 02042 dated 11/26/2007, Agrovetzashchita NVC LLC (Russia), manufactured by: AVZ S-P LLC (Russia)
• COLLAR INSECTOACARICIDAL BARS® - polymer tape, reg. No: PVR-2-5.7 / 02023 dated 09/19/2007, AgroVetzashchita NVC LLC (Russia), manufactured by: AVZ S-P LLC (Russia)
• FIPREX 75 SPOT-OH - solution for external use, reg. No: PVI-2-2.9 / 02726 from 04/08/2009, Vet-Agro sp.z.o.o. (Poland)
• FIPREX SPRAY FORTE - solution for external use, reg. No: PVI-2-2.9 / 02727 dated 04/08/2009, Vet-Agro sp.z.o.o. (Poland)
• INSPECTOR TOTAL K - solution for external use, reg. No: PVR-3-7.12 / 02838 dated 06/06/2012, NPF ECOPROM (Russia)
• INSPECTOR TOTAL C - solution for external use, reg. No: PVR-3-7.12 / 02839 dated 06/06/2012, NPF ECOPROM (Russia)
• FIPRIST® SPRAY - solution for external use, reg. No .: 705-3-21.12-1115 No. PVI-3-21.12 / 03840 dated 09.11.2012, KRKA d.d., Novo Mesto (Slovenia)
• FIPRIST® COMBO - solution for external use (for dogs), reg. No: RK-VP-4-3172-16 from 07/22/2016, KRKA d.d., Novo Mesto (Slovenia)
• FIPRIST® COMBO - solution for external use (for cats and ferrets) 50 mg + 60 mg / 0.5 ml, reg. No .: RK-VP-4-3173-16 from 07/22/2016, KRKA d.d., Novo Mesto (Slovenia).

Pharmacological (biological) properties and effects

Contact insecticide drug. It is active against all phases of the development of lice, fleas, lice, and ticks (ixodidae, cheilitis, otodectosa) parasitizing on dogs and cats.

The mechanism of action of fipronil, which is part of the drug, is to block GABA-dependent arthropod receptors, impaired transmission of nerve impulses, which leads to paralysis and death of ectoparasites.

After applying the drug to the skin, fipronil is gradually distributed over the entire surface of the body for 24 hours and, practically not absorbed into the systemic circulation, accumulates in the epidermis,hair follicles and sebaceous glands, providing a long contact insecticide and acaricidal action, protects the animal from ectoparasites.

Fiprist® Spot It belongs to moderately hazardous substances by the degree of exposure to the body (hazard class 3 according to GOST 12.1.007-76), at the recommended doses it does not exert a locally irritating and resorptive toxic effect, and if it comes into contact with the eyes, it causes slight irritation. The drug is toxic to rabbits, as well as fish and other aquatic organisms.

Indications for use of the drug FIPRIST® SPOT OH. Dogs and cats from 8 weeks of age with:

Application procedure

Fiprist® Spot It is used in animals by a single topical application of the drug to dry, intact skin, using pipettes of various packaging (depending on the type and weight of the animal).

Before processing, the tip of the pipette is punctured with an inverted cap, the animal’s fur is spread in the back (between the shoulder blades) and, by pressing the pipette, the preparation is applied to the skin at one or more points in the following doses:

The duration of the protective effect of the drug against ixodid ticks after treatment of cats is 15-21 days, after treatment of dogs - up to 1 month. Duration of protective action against fleas: after treatment of cats - up to 1.5 months, after treatment of dogs - 2-2.5 months.

Repeated treatment of animals is carried out according to indications, but not more often than 1 time in 3 weeks.

For the treatment of otodectosis, Fiprist® Spot It is instilled into each ear 4-6 drops (drops must be introduced into both ears). For uniform distribution of the drug, the auricle is folded in half and lightly massaged at its base.

The remainder of the drug in the pipette used (based on the weight of the animal) is applied to the skin between the shoulder blades (single treatment). With the complication of otodectosis, otitis is prescribed antimicrobial and anti-inflammatory drugs.

There were no specific features of the action of the drug during its first use and withdrawal. Violations of the regimen of the drug should be avoided, as this may lead to a decrease in its effectiveness. If the next treatment is skipped, it should be carried out as soon as possible in the same dose.

Side effects

When using the drug in accordance with the instructions, side effects and complications in animals, as a rule, are not observed.

Contraindications to the use of the drug FIPRIST® SPOT OH: increased individual sensitivity of the animal to the components of the drug (including history).

The use of the drug is prohibited:

• patients with infectious diseases and weakened animals;
• dogs weighing less than 2 kg;
• puppies and kittens younger than 8 weeks of age.

special instructions

Personal Prevention

When working with the drug Fiprist® Spot It, you must follow the general rules of personal hygiene and safety precautions provided for when working with medicines.

During work, it is not allowed to smoke, drink or eat food. At the end of the work, wash your hands with warm water and detergent. Within 24 hours after treatment, the animal should not be ironed and kept out of the reach of young children.

If the drug accidentally gets on the skin or mucous membranes, it should immediately be removed with a swab and then washed off with water and a detergent; if ingested, give a few glasses of warm water, enterosorbent to drink and, if necessary, contact a medical institution (carry a label or instructions for use).

When destroying an unused drug, it should not be allowed to enter natural water bodies or sources of drinking water.

Terms and conditions of storage

The drug should be stored in the manufacturer’s sealed packaging, separate from food and feed, in a place protected from direct sunlight, out of reach of children, at a temperature of 0 ° to 25 ° C. Shelf life subject to storage conditions is 3 years from the date of production.

It is forbidden to use the drug after the expiration date. Unused drug is disposed of in accordance with legal requirements.

Medicines for animals. Fipronil (spray)

Short description: this remedy has a pronounced insect-acaricidal effect, since it disrupts the transmission of nerve impulses in parasites and causes paralysis in the latter. Finpronil has a detrimental effect on fleas, lice, ixodid ticks, lice beetles, heiletiella and causative agents of ear scabies.

The information on this page is for guidance only and cannot be used for self-medication! Before using the preparations, a consultation with a specialist is MANDATORY!

This veterinary drug is practically not absorbed through the skin of animals. It accumulates in the sebaceous glands, due to which for a long time it protects animals from insect-acaricidal diseases.

Veterinarians prescribe this medicine to animals mainly in order to prevent infection and get rid of parasites such as ticks (Dermatocentor, Rhipicephalus, Ixodes), fleas (Ctenocephalides), and carnivores. Finopril is also used to prevent flea allergic dermatitis.

For whom: assigned to cats and dogs.

Vacation form: this preparation in the form of a clear (or purple) solution is packaged in special bottles having a nebulizer with a volume of 250 or 100 ml. The solution has a specific odor.

To accelerate the penetration of the drug into the skin, it is recommended to rub it lightly with rubber gloves. The approximate dosage of the drug is 3-6 ml for every 1 kg of animal weight.

Do not allow animals to lick this insect-acaricidal agent from the surface of the coat or skin. You can wash your pet (or allow him to swim in ponds) no earlier than 48 hours after applying the medicine.

To prevent re-infection with parasites, the litter of a dog or cat should be disinfected or replaced. Usually a single use of the drug is sufficient. According to the prescription of the veterinarian, the treatment of pets is repeated 1 time every 1-3 months.

Drug licking can cause symptoms in the animal, such as increased salivation, the occurrence of skin erythema, itching, and in rare cases, vomiting and difficulty breathing. This medication is contraindicated in rabbits.

Means for fleas and ticks

Perhaps not a single direction in veterinary medicine has grown as fast as the fight against parasites in domestic animals. New flea and tick remedies are constantly being invented, but the parasites become immune to many remedies over time and as their numbers increase, tremendous efforts are required to control them.

Ticks can transmit many diseases, so the fight against ticks is also given great attention. Today's insecticides for pets have made a significant breakthrough, a large number of new products for fleas and ticks have been produced.

You can usually read this information on product packaging. It will be useful for any pet owner to find out the important differences between one product and fleas from another and choose the most suitable option for your pet.

So, today on the shelves of pet stores we are mainly offered flea and tick products from Bayer (Advandix, Bolfo, Kiltix), Hartz, Beaphar, Frontline, Promeris, Stronghold and domestic preparations Bars, etc.

The main active ingredients of these funds are the following components.

Pyrethrins

Pyrethrins are one of the most widely used insecticides in modern flea and tick remedies, in this quality they have been used for over 100 years. Pyrethrins are natural extracts from chrysanthemum flowers. There are six types of pyrethrins.

All six are used in products from fleas and ticks, however, the active ingredient ‘pyrethrin’ is usually indicated on the product’s packaging, regardless of which type of six is ​​actually used.

Method of action: Pyrethrins act on the nervous system of insects and lead to repeated and extensive ruptures of nerves. The effect is achieved by affecting the flow of sodium from nerve cells.

Use: Pyrethrins are used to kill ticks, fleas, lice and mosquitoes. Pyrethrin-based products are usually applied directly to the animal. Flea remedies for home treatment usually contain pyrethrins, or a combination of pyrethrin and permethrin (see below), or pyrethrins plus a synergist. Synergists are chemicals that enhance the action of other drugs.

Safety: The possibility of intoxication in animals is very low, but possible. Symptoms of pyrethrin poisoning in animals may include: salivation, trembling, and vomiting. Usually, symptoms of intoxication disappear after 24 hours.

The most common synthetic pyrethrins used to control fleas and ticks are phenotrin, etofenprox, and permethrin. They act slower than natural pyrethrins, but have a longer effect.

Method of action: Pyrethroids, like pyrethrin, act on the nervous system of insects.

Use: Pyrethroids are used to produce flea, lice and ticks. Since the action of permethrins is longer, in comparison with natural pyrethrins, they are usually used in sprays, shampoos to increase the time of the protective effect.

Products for cats contain etofenprox, which is indicated on the packaging as a means for cats.

Safety: some animals may experience temporary sensitivity to pyrethroids. Symptoms of poisoning as with pyrethrin poisoning.

Organophosphates and organocarbamates

Organophosphates and carbominic acid derivatives are another class of agents used as insecticides for farm and domestic animals. Organophosphates and carbominic acid derivatives are widely used such as: organophosphorus (thiophos, karbofos, methyl mercaptophos, dichlorvos, diazinon, etc.), carbamic acid derivatives (methyl carbamate, propoxur).

Use: Organophosphates are widely used in agriculture to get rid of earthworms and cattle parasites. Organophosphates should not be used on cats.

Safety: Organophosphates and carbominic acid derivatives are a class of insecticides that are most likely to cause toxic poisoning in pets. Symptoms in a pet with organophosphate poisoning include: breathing problems, hind limb weakness, increased salivation, limb tremor

Greyhounds and hounds can be overly sensitive to organophosphates, so it’s best to use other flea remedies for these breeds.

Imidacloprid (imidacloprid)

Imidacloprid is a new insecticide that belongs to a different class of chemicals and is used in the production of flea products.

Mode of action: Like most insecticides, imidacloprid acts on the nervous system of insects, blocking nerve receptors. This kills fleas but does not affect ticks.

Usage: Imidacloprid is usually used once a month as an external flea insecticide for cats and dogs. Imidacloprid mixed with oily solvents is collected in the follicles of the wool, from where it is slowly released.

Safety: Imidacloprid is a fairly safe substance, but along with other components, when used in some pets, sensitivity to it may develop.

Fipronil (fipronil)

Fipronil is the most used substance in a relatively new group of synthetic insecticide products. Mode of Action: Paralysis of parasites.

Safety: Together with other components, some pets may experience temporary sensitivity at the application site. Some animals may develop more severe sensitivity. In this case, it is best to consult a veterinarian.

Metaflumizone (metaflumizone)

Metaflumizone is an insecticide of guppa of semicarbazone used in the production of flea medications.

Method of action: Metaflumizone attacks the nervous system of a flea, blocking the movement of sodium atoms. This leads to paralysis and death of the flea.

Safety: Some animals may experience temporary sensitivity at the site of use of the product or more serious sensitivity, in which case it is recommended to consult a veterinarian.

Amitraz (amitraz)

Amitraz is a component that is used to treat demodectic scabies. Amitraz has also been shown to be highly effective when used in dog collars against ticks. It has no effect on fleas, therefore it is used only to control ticks. Do not use amitaz on cats.

Use: Amitaz has been shown to be effective in combating ticks compared to other products such as organophosphates.

Most ticks die in less than 24 hours, thus preventing the transmission of Lyme disease. Amitaz is also used in other flea products as a component that provides protection against ticks (check the information on the package).

The amitase concentration in the collars against ticks is not high enough to provide prophylaxis against demodectic scabies.

Amitraz cannot be used on cats.

Safety: Collars containing amitaz are safe for dogs if used correctly. The collar should be dressed so that you can stick two fingers between the collar and the dog’s neck - no more, no less.

If the collar is too tight, it can cause skin irritation. Make sure that the excess part of the collar is cut off and that the dog or other pet cannot reach the end of the collar.

Selamyctin (selamectin)

Selamiktin is a new semi-synthetic avermectin, the main active ingredient in the treatment of fleas, ticks and other parasites of the brand Stronghold and Revolution.

Mode of action: Selamectin kills parasites by blocking the transmission of nerve signals.

Usage: Selamectin is an external insecticide used to combat fleas, ear mites, some internal parasites, ticks and the prevention of dirofilariasis. More than 98% of fleas on a pet die within 36 hours after use. After contact with the product, fleas will not be able to lay viable eggs.

Safety: Do not use this product on kittens or puppies under 6 weeks of age. Use caution when using this remedy on patients who are weakened, underweight, or animals with skin problems.

Nitenpyram (nitenpyram)

Nitenpiram has been shown to be effective in fighting fleas in cats and dogs. A distinctive feature of the Nitenpyram-based Capstar flea remedy is the oral route of administration. Method of action: Nitenpyram block nerve receptors in fleas.

The peak effect after taking the drug is approximately 3 hours for the dog and 4 hours for the cat. This is very convenient in certain circumstances, such as surgery, transportation, haircuts, etc.

Safety: Nitenpyram is quite safe. It can be used for kittens and for puppies from 4 weeks and older, weighing from 1 kg., As well as for pregnant animals.

Fipronil cockroaches

In the modern world, the chemical industry is working hard for the benefit of man. And a certain part of it is trying for household and industrial chemicals to counter various insect parasites.

What it is?

Fipronil (also known as Regent, Cosmos and Adonis) is a pesticide (a class of phenylpyrazoles). A modern product designed to kill insects. Refers to insecticides and agricultural acaricides. The affinity is popular, so it is increasingly being asked if there are problems with parasites.

Fipronil served well and, unlike Dust, was not banned. In Russia, fipronil has also been a guardian of agricultural fields and ordinary Russian apartments for a long time.

Where it is applied and how it acts

In fact, this is a widespread use insecticide, which appears in many industrial and domestic insect repellents. The principle of action is based on the toxic effects on insect cells, leading to their destruction.

The central nervous system of insects, due to the blocking of GABA-related chloride and glutamate tubules, results in an almost complete stop of the transmission of nerve impulses. It is used as in everyday life - means to combat bugs, ants and cockroaches; and cultural pests in the agricultural sector - in fields, forests, etc.

It is delivered in the form of:

• 80% Water-dispersible granules;
• 4% Emulsion Concentrate.

Application efficiency

It is quite effective, considering the initial properties of fipronil. But most often it is contained as one of the components of the poison, so the end result may vary.

But most of all, parasite remedies hit ants and cockroaches, as the intestinal contact effect is enhanced when the substance gets inside. Actually, this happens quite often, because insects do not find fipronil unpleasant in taste.

It is also known that poisoned individuals of cockroaches die quite slowly, but surely. During this time, they manage to get deeper, where they will defecate with feces containing processed poison.

After death, cockroaches eat their relatives, which only enhances the effect, because fipronil is easily stored in insect corpses in a dose sufficient for poisoning.

The situation with ants is even more pleasant. The individuals responsible for delivering food to the anthill do not have time to die immediately after the test (as is the case with ordinary poison), but have time to convey the bait to the uterus. This makes a very significant contribution to the fight against parasitic ants. Residual effect: high.

Fipronil toxicity

Unfortunately, the slaughter properties of the pesticide do not cancel the harmful effects of the poison on the environment and animals. The first thing, of course, is the damage to animals. Most often, birds and small warm-blooded pets suffer. In their body, as well as in the body of fish / invertebrates, the poisonous substance has the ability to accumulate.

Verdict: Ready for use. Extremely effective. Recommended for household treatments.