Bravecto - a tablet from ticks: principle of action, use, reviews

Good day. On a nearby street six months ago there was a tragic incident.

For one week a granddaughter came with her beloved dog. Before leaving, the dog was bitten by a tick, and after another three days, his beloved pet was gone.

Later, acquaintances told them that it was necessary to use the drug Bravecto to save the pet. Want to know the principle of action of the tablet from Bravecto ticks? How can she help a dog survive a tick bite without complications? Now I will describe everything in detail in the article below.

Antiparasitic products Bravecto - reviews

Any dog ​​lover knows that ticks are a terrible scourge. And the worst thing is that you can pick them up not only in the forest and outdoors, but also in the city, right next to the house. I think we should not tell how dangerous the ticks are: if someone did not come across it, they probably heard how they tried to save familiar dogs for a lot of money - after all, a dog can die from an infected tick bite in 3 days ... Sad

So, we have a husky. Of course, we constantly examined him on the topic of ticks, but in his very dense coat and undercoat you can see the tick only on the surface, if it went down a little closer to the skin - the chances are almost equal to 0 (there were situations when you found an already ticked tick for a second they let go to grab a hand, and then together with her husband they searched for 40 minutes - after all, he was definitely somewhere here).

We used to treat a dog drops + spray. Drops of Hartz or Advantix, sprays of Bolfo and Bars. There was no special effect: the mites still dug in and continued to live. Then I read that for long-haired dogs, sprays are basically a waste of money.

Immediately make a reservation: contrary to popular belief, neither a drop nor a spray repels ticks, the principle of operation is the same as for Bravecto: the tick bites, paralyzes and falls off (only the action occurs through subcutaneous fat), but in our case I did not see any dried up drops tick.

In addition, drops / spray has another significant drawback - the prohibition of bathing before and after for several days. For our dog who loves water, this is a real test.

When they learned about Bravecto, they were cautious: after all, a tablet, a substance enters the blood, plasma and all other fluids, suddenly it can strongly affect the stomach, liver, etc. But we were convinced that the reviews are very good.

How we started using Bravecto

And so we gathered a dog in Latvia, in a region where there are sooo many ticks. For Hasya it was scary, because ticks for us remained an unresolved problem.And they remembered about Bravecto. Once again we talked with our veterinarian, re-read the studies on the Internet ...

So, the main points that motivated us to give the pill:

• promised 99% tick protection;
• according to American studies, none of the tested dogs had any side effects (although it seems that in the European version they write about a possible decrease in appetite, apathy, etc.);
• principle of action: at the time of a bite, the tick is paralyzed due to the active substance (fluralaner). Preventing questions: a common misconception is that if an infected tick bites, the dog is immediately infected. In order for the infected tick saliva to spread, it must first drink blood. As a rule, it is from 7 to 24 hours. Only then it becomes dangerous for the pet. Bravecto, on the other hand, acts at the very moment when the tick bites: it paralyzes, dries out within a few hours and falls off after a while. But already from the first second he cannot drink blood.

And we decided. At that time, our dog was 6 months old, he weighed somewhere around 20-20.5, but we gave him a tablet for 10-20 kg (now we take tablets for large dogs weighing 20-40 kg).

Also, Bravecto can be taken with drops / collars / sprays, etc. from ticks, anthelmintic drugs, antibiotics, and almost any other drugs, this does not cause any unwanted reactions and does not reduce the effectiveness of the pill.

The next few days after the first application, I looked at the dog more than ever, but there were no changes in behavior, in activity, in appetite, or in stool. A dog is like a dog.

A few days later we went to the lake in the forest 🌲🌳🌲, where, as it turned out later, there were darkness with ticks (we even bit a person). I was very worried about the dog, I knew that until I saw a dried tick, I would not rest. It seems that they looked at it many times, but did not find ticks.

Only after a couple of days, combing it out, at first they found one dried up, then the second ... in total, about 8 ... Over the next couple of months, dried ticks were found repeatedly, but this did not affect the health of the dog in any way. In general, we were very pleased that finally such a miracle pill appeared now))

Now the third tick season has already begun the year we use Bravecto. Impressions are extremely positive: there were a lot of ticks, all always dried up. There were times when these pills disappeared in our city, I had to order from the capital ... But I can’t imagine any other protection against ticks: it’s simple, convenient, and most importantly, effective!

So, the undoubted advantages:

In the package with the tablet there are 3 stickers for the veterinary passport, it is very convenient to remember the date of the previous tablet.

We have been using Bravecto for the past 3 years and sincerely recommend it to all familiar dog lovers!

Dog reviews

Mixaluch: I must say right away that I registered specifically to write my review about the use of the Bravecto tablet and describe the results of this use. I have a German shepherd, a large male lohmach weighing about 50 kg., Age 4 and a half years. We from Kiev used to use flea and tick protection in the form of a Foresto collar and drops at the withers.

For the first time about a miracle tablet, “Bravecto” I heard from a salesman in a pet store, as a novelty in the Ukrainian market and as a drug that has proven itself well abroad. Using the Internet, I found out for myself that the tablet manufacturer is a well-known Austrian company MSD, which widely advertises its products.

It first appeared on the market of the CIS countries in Belarus, Russia and Kazakhstan, where it was officially approved for use, and from this year it appeared in Ukraine. Naturally, I was interested in reviews from those who directly used the tablet to their dogs, and did not repeat the manufacturer’s advertising or told someone else's words.

On the Internet, I found the most reviews from residents of Russia and, as a rule, everyone only praised the MIRACLE TABLET. For the purpose of objectivity of information, he specially created a topic at the Russian forum of “non-maths”, where I often communicate with fellow dog lovers, but there were practically no feedback from the owners who directly used the tablet.

I bought a tablet in the ZOO online pet store ([link]), and they were from the official distributor in Kiev - “VETBIO” so that the tablet was real (checked). When I offered the dog a pill, he didn’t want to eat it; I had to put it back on the root of the tongue feed him his head.

On the first day, the dog was a little lethargic, but did not regurgitate the pill and everything else was fine (as usual). Walking in the city “under the pill” while examining the dog I did not find any ticks either on the dog or near it. This continued until March 18 of this year.

On this day, we went to the "field". I have not wore Foresto so that the dog was protected only by the miracle of the Bravecto pill. Walking in the wasteland for about an hour, I noticed a crawling tick on the front paw of a dog, which I immediately removed and destroyed, and when I brought the dog home I examined it for crawling or digging ticks, but I did not find anything at once.

After about an hour and a half, I noticed a creeping tick from the dog bed. I don’t know whether the tick itself fell away or not, but I also destroyed it. Having examined the dog again, I didn’t find anything on it (I have it long-haired). Near the bedding for the dog I found several small dead ticks.

And after 6-8 hours after a walk in the wasteland, when he was going to take Sobakevich in the evening for an evening walk, he noticed a tick biting his head on a dog’s head near his ear. In this case, the dog was in normal normal condition.I took her to the veterinary center of Kalmykova EN, where the dog is being served and there the veterinarian removed a lively tick from the dog-breeding LIVING.

The next day, I also found dead ticks near the dog's bedding and one living half-drunk crawling to the side. Naturally, I carefully monitored the behavior of the dog and its condition after removing the biting and living tick (as the veterinarian recommended), but the condition was normal and I even thought that the tick was not contagious.

But after 4 days, or rather on the night of March 22 of this year Sobakin woke me up at half past four in the morning and persistently called out. While I was preparing, the dog started vomiting (he pulled out the food taken at 6 o'clock in the evening of the last day and which was not digested (dry food).

Thus, as a result of using the miracle of the Bravecto tablet, I came to the following conclusions that at the first contact with ticks on the 18th day of using the tablet, the tick digged into the dog and infected it and remained alive. So I really regret that I was seduced by the laudatory reviews about the pill, that it was supposedly “not punched” by ticks.

Nonsense! I was convinced from my experience. In addition, the same was confirmed in the veterinary center, saying that they are already their second such "infected" under the tablet "Bravecto". And it turns out that the tick introduces babesia when the dog bites along with the saliva where they are.

Thank you for your health, but I bought a tablet (expensive) in order to preserve this health of the dog, and it turns out that it was lost due to unscrupulous advertising by the manufacturer. Plus, money for treatment, examination and restoration of the liver and kidneys and the purchase of another protective agent.

Sasha1987: Hello! I registered only to leave comments about Bravecto. So my story. I have a German, age 1 year 7 months. Back in February of this year, our trainer very much advertised this Bravecto tablet as the best protection against ticks.

We then did not succumb to persuasion and did not buy anything. In mid-April, we went out into the countryside and collected a bunch of ticks, both on ourselves and on the dog. Immediately went to the veterinarian and bought Bravecto for dogs 30-40kg. Dogevich ate the pill with pleasure. It was 04/16/2016. Yesterday afternoon (05/02/2016) the German became sluggish, refused food, barely walked.

At first they thought that they had eaten something wrong, because they were sure of protection against ticks. 05/03/2016 at 07.00 in the morning the dog was taken to the veterinary clinic, where they took a blood test and said that he had pyroplasmosis. They made a German a dropper, injections of various medicines and vitamins. For another 5 days, droppers.

So think for yourself how reliable this drug is. And do not talk about 1%, which falls ill. There are too many cases.

Bravecto for dogs: instruction, use, reviews

The Bravecto® tablet form is a new way to protect dogs of all breeds from blood-sucking parasites. The preparation contains active substances that protect the four-legged pet from ectoparasites and dangerous diseases transmitted by fleas, mosquitoes, ticks for 12 weeks.

Oral tablets are used both for prophylactic and therapeutic purposes. The tool is used in the fight against allergic dermatitis and aphanopterosis, as well as acarosis caused by ixodid ticks.

Operating principle

An antiparasitic agent with the trade name Bravecto® (Bravecto) is a tablet form for oral administration. A new drug in the veterinary market is classified as a systemic insecticide and acaricide.

Depending on the dog’s weight, tablets are available in five dosages. They have a different size and percentage of fluralaner as an active substance.

The mechanism of action of the drug on the animal’s body is that fluralaner binds to blood plasma and blocks GABA-dependent and glutamate-dependent ectoparasite receptors.

By its action, it causes hyper-excitation of neurons of blood-sucking parasites, disrupting the transmission of nerve impulses. As a result of disorders caused by fluralaner, parasites occur in fleas and ticks, which leads to their death.

Pharmacodynamics

Absorption of an active substance by the digestive tract is very high. Fluralaner penetrates the systemic circulation and reaches a critical mass in blood plasma during the day with bioavailability of up to 20-27%. Feeding a pet before giving a pill enhances the absorption of the components of the drug.

The action of Bravecto is aimed at the destruction of parasites. The complete death of fleas is observed, 8 hours after taking the drug, ticks - 12. The drug helps to prevent secondary infection of the animal for up to 12 weeks.

Fleas die before laying eggs, which is a preventive measure to clean the room where dogs are kept from secondary parasite damage due to the absence of clutches and the development of larvae.

Mode of application

In addition to the main action of the drug aimed at the destruction of ectoparasites, Bravecto is used in complex therapy in the treatment of allergic dermatitis in dogs caused by insect bites. Chewable tablets are given to dogs orally, immediately at the time or after a meal, because food helps to fully absorb the active ingredient.

Chewable tablets have an attractive smell and taste for dogs. Animals, as a rule, eat a remedy against ectoparasites with pleasure. If you refuse the drug, the dogs are given a tablet forcibly. Then make sure that the pet has completely swallowed the required dose.

For an animal weighing more than 56.0 kg, it is recommended to combine two tablets of different dosages, counting on 25 kg of active substance per 1 kg of dog weight.

Re-treatment of the animal from ectoparasites is carried out after 12 weeks, and not three months. Therefore, it is better to write down the date of taking the drug and mark on the calendar the day of the next intake of the tick and flea remedy.

Contraindications

Oral tablets by animals are generally well tolerated. Only in some cases there is an indigestion, excessive salivation or refusal to feed.

The drug has contraindications, and it does not give:

1. Small breeds weighing up to two kilograms.
2. Puppies under two months of age.
3. Productive animals.

Combination therapy is not an obstacle to taking the drug, it can be given:

• steroids;
• corticosteroids;
• antibiotics.

Studies have shown that, using Bravecto in complex therapy, side effects are not observed, the possible manifestation of reactions can be attributed to the individual characteristics of the animal's body.

Reviews

Irina, owner of the Jack Russell Terrier: For my pet, the drug did not fit. I believe that it should be given with a massive lesion of the animal by ectoparasites, so as not to suffer, manually removing clusters of ticks from the dog.

Give a pill, and the ticks really all fall off. I consider Braveto an excellent tool for volunteers serving shelters.

Elena, owner of the Labrador: The tool, of course, is better than traditional drops, since its effect extends for almost three months. But all the same 4 hours after taking the pill, how the drug begins to act. As with drops, fleas die, after 8, ticks - 12 hours.

Dmitry, veterinarian: Once in the dog’s body, an active substance penetrates the blood and lymph and has a paralytic effect on ectoparasites. The tick may also move for several hours, but internal paralysis of organs with a bite occurs almost instantly.

Even if tick saliva affected by babesiosis enters the dog’s body, one should not forget that the life cycle of babesia is one day. And the active substance contained in the blood will prevent the maturation and development of the infection.

Average cost in Russia

The price of tablets from Bravecto ticks for dogs on average in the Russian Federation is:

Analogues of the drug

Only two drugs can be attributed to analogues of chewing tablets for dogs Bravecto - Neskgard and Frontline, both produced by TM Merial.

If you used Bravecto for your dog, be sure to share your impressions: how effective and safe it seemed to you, how the pet underwent treatment, what can you advise to those who are going to buy the drug.

We fight with ticks attacking the dog

Ixodid ticks are parasitic organisms that are ubiquitous and live mainly on grass, shrubs, trees. Therefore, it is clear that it is almost impossible to protect a dog who regularly takes walks on the street from them.

The most wary of ixodid ticks should be in March-May and August-October. Keep this in mind when handling your pet. Ixodid tick - a large parasite, it can be seen on the body of the animal with the naked eye.

And signs that your pet has been bitten by a dangerous tick may be:

Babesiosis can become fatal if you do not help the animal in time. In addition, if you find a sucking parasite in the body of your pet, it is strongly recommended that a blood test be performed. It usually takes a little time, but it will definitely become known about the presence or absence of babesias in your puppy's blood.

In addition, after each walk, it is advisable to inspect the dog in order to find a neighbor in it. The most favorite place for the mite to dislocate is the head, neck, ear area and inguinal zone.

Drops. Fortunately, modern veterinary medicine is replete with means that can protect your pet from ticks, and drops at the withers are the simplest and most common remedy. Drops are acaricidal substance in high concentration.

Drops are applied to the withers of the animal, sometimes a few drops also drip along the spine. It is believed that the drops begin to act a day after application. For puppies and pregnant bitches, there are special “gentle” drops on the withers, for example, Front Line Spot.

In principle, treating dogs with drops is recommended once a month, and in the summer even more often.

After all, the animal walks in the dew, can bathe in water, and from this the protective properties of the drops are reduced. In addition, puppies of small breeds after morning walks may even be completely wet.

Most veterinarians give positive feedback to tick drops such as Front Line, Advantix, and Inspector. By the way, drops on the withers of the Inspector also provide protection against fleas and worms. A good domestic remedy for ticks for dogs is Bars drops.

Tablets. Tick ​​tablets are less common than drops. Their principle of action is based on the fact that in a dog or puppy who has eaten a pill, the blood becomes “tasteless” for the parasite. Tablet preparations are a new generation of flea and tick protection products and are very convenient to use.

According to the instructions, these drugs are used every 12 weeks, it is for this period that they provide continuous protection. They begin to act almost immediately after administration. Moreover, Bravecto and Nexguard are very tasty, dogs eat them with pleasure, they are suitable for dogs of all breeds and are not dangerous for puppies from 2 months of age.

Bravecto tablets contain the active substance fluralaner in different concentrations for different breeds of dogs, from small to large. Bravecto will also protect your pet from fleas.

Sprays. Sprays are an alternative means of protection against ticks and fleas, they are recommended to be used with a frequency of 10-14 days. Sprays are not very suitable for use on dogs of large breeds, because for good protection the dog should be completely sprayed.

But for small breeds, sprays are quite suitable. The most popular sprays are Frontline and Fiprist. Aerosols are similar to the spray mechanism of action; the most popular aerosol sprays are Bolfo and Bars.

Destroy the subcutaneous tick

The subcutaneous tick, which can be dangerous for our pets, is represented by two subspecies: sarcoptes and demodex. Moreover, the first of them is contagious and can be transmitted from one dog to another. And the second subcutaneous tick is not contagious and is transmitted “by inheritance” from the mother to the puppies, while being a normal resident of the skin.

Demodecosis complicated by a secondary microbial infection can cause serious lesions in the form of severe scratching and purulent inflammation of the skin. An advanced treatment for generalized dog demodicosis is the use of Bravecto chewable tablets.

At the same time, to cure this difficult disease, it is enough to take one Bravecto tablet.But if the manifestations of a bacterial infection are also pronounced, in addition to Bravecto, it is also advisable to use antiseptic shampoos and sometimes antibiotics.

Sarcoptosis, better known as scabies, most often affects young puppies or adults, which are found in inappropriate conditions on a low-quality diet. Sarcoptosis is manifested by very severe itching in the head and paws, as well as the formation of crusts on the affected areas of the skin.

For treatment in this case, double treatment with drops at the withers of the Inspector or Lawyer Stronghold is necessary. Inspector Drops are generally effective against many ticks.

We fight with an ear tick

The tick that lives in the ears of our four-legged pets is called otodectes, and the disease that it causes is called otodectosis. Otodectosis outwardly looks like an abundance of sulfur secretions in the ears. In addition, ears affected by otodectosis strongly itch and deliver an unpleasant sensation to the animal.

Puppies, especially small breeds, are subject to otodectosis, according to veterinarians, adult dogs are less likely to suffer from otodectosis. Infection with otodectosis occurs as a result of contact with a sick individual.

Before starting treatment, the patient’s ears must be thoroughly rinsed and rid of the accumulated sulfur with special hygienic solutions and drops. If bacterial inflammation of the skin has already developed on the background of otodectosis, then the use of antibacterial ear drops is necessary.

The next step in the treatment of otodectosis is the use of anti-tick drugs, and Bravecto is not suitable for this case. Ear drops against parasites are quite common, however, are an ineffective treatment and cause great discomfort when instilled into the ears.

Drops at the withers, such as the Inspector or Lawyer Stronghold, are a more effective way to combat otodectosis. To completely cure otodectosis, with the exception of possible relapses, Inspector drops are used twice with an interval of 1 month. By the way, when applying the drops of the Inspector, side effects were not noticed.

The lethal rate of fluralaner (Bravecto ™) on Ixodes ricinus ticks in dogs

Tick-borne pathogens of dogs, in particular babesiosis, anaplasmosis, borreliosis and ehrlichiosis, are an increasingly serious problem throughout the world. One of the methods for the prevention of these vector-borne diseases is the destruction of ticks before the transmission of the pathogen to the dog.

Fluralaner (Bravecto ™) is a new systemic isoxazoline insecticide and acaricide with a long-lasting and stable antiparasitic effect. This study examines the rate of lethal action of fluralaner on ticks in dogs.

General information

Ticks are a serious problem for humans and animals, as they not only feed on the blood of hosts, but also carry numerous pathogens, in particular viruses, bacteria and parasites. When fed, infected ticks can transmit pathogens to both humans and domestic animals, particularly dogs.

Tick-borne diseases can be prevented by avoiding the places populated by ticks and physically removing ticks from the body of affected dogs. A more reasonable approach is the use of repellent drugs or agents that can quickly kill ticks before transmission of pathogens, preferably with a long duration of action.

Fluralaner (Bravecto ™) - an innovative ectoparasiticide belonging to a new class of compounds, isoxazolines, is effective against Ixodes ricinus, Ixodes scapularis, Dermacentor reticulatus, Dermacentor variabilis and Rhipicephalus sanguineus, i.e. against all types of ticks capable of transmitting the most important pathogens of human and domestic animals, in particular anaplasmosis, babesiosis, borreliosis and ehrlichiosis.

The mechanism of action of fluralaner is based on the blockade of ligand-dependent chloride channels (both GABA receptors and glutamate receptors), which leads to suppression of the arthropod nervous system, which leads to paralysis and death of fleas and ticks.

In dogs, fluralaner is characterized by a long half-life, a long retention time, a relatively high volume of distribution and low clearance. The long retention time of fluralaner in the dog’s blood plasma causes stable lethal activity against fleas and ticks for 12 weeks after a single oral administration.

For the action of fluralaner, it is necessary that the ticks attach to the skin of the host and, thus, swallow the active component. Continuous feeding increases the risk of transmission of pathogens from ticks to dogs, however, infection usually does not occur immediately after the tick is attached to the dog.

For the transmission of most diseases transmitted by ticks, initial attachment and a period of bloodsucking of at least 24-48 hours, during which pathogens reactivate, are necessary. This period between tick attachment and transmission of the pathogen allows fluralaner to exert its effect.

Based on the justification indicated above, 2 studies were conducted to assess the rate of tick destruction by fluralaner. For this, the efficiency of killing ticks was measured after 4 and 8 hours (study 1) or after 12 and 24 hours (study 2) after a single use, as well as at various intervals after re-infection of these dogs during the 12 weeks of the drug.

In both studies, I. ricinus ticks were selected to infect dogs.

Study design

Studies have examined the rate of lethal action of fluralaner on I. ricinus ticks in dogs. The study included a total of 48 healthy adult Beagle dogs (<7 years old) who were not treated with any antiparasitic drug for at least 12 weeks before the start of the study.

Before distribution into groups of dogs weighed (range 9.3-19.9 kg) and conducted a clinical examination. Participating dogs had previously been infected with 80 fleas (Ctenocephalides felis) to demonstrate their susceptibility to parasitic infestation and to confirm the absence of ectoparasiticides.

Dogs were ranked in decreasing order of fleas (in the range of 63-80 fleas / dog) and randomly assigned to 8 groups (4 treatment groups and 4 corresponding control groups) of 6 dogs using a computer-generated randomization list.

All dogs were kept indoors. During periods without parasitic infestation, dogs were kept in the groups in which they were distributed, and during periods of parasitic infestation, all dogs were kept separately.

The temperature in the vivarium with dogs was 17-22 ° C, and relative humidity - 40-90%.Dogs were fed standard, commercially available dry dog ​​food once a day, and access to water was not restricted. General health observations were made once a day throughout the study.

Drug use

On day 0 (i.e., the day the drug was used), dogs in 4 experimental groups received chewable tablets of fluralaner based on the body weight of a particular animal and a minimum dose of 25 mg fluralaner / kg of body weight.

Each dog was continuously monitored for 1 hour after administration of the drug to determine whether the chewable tablet would spit out or burp; such cases did not occur. Dogs in 4 control groups were left without treatment.

Tick ​​infection and its assessment

The ticks I. ricinus used in the study were grown in the laboratory for at least 2 generations after selection from natural habitats in Europe. Dogs under the influence of the sedative drug medetomidine were infected with ticks at 2, 28 (4 weeks), 56 (8 weeks) and 84 (12 weeks) days.

At each infection, 50 non-fed adult female ticks were placed directly on the hair of each dog along the back, on the side and on the head. In addition, 10 Ixodes ricinus males were placed on the dogs to provide the females with optimal conditions for attachment. Tick-infected dogs were kept in individual pens until parasites were removed.

The entire body of each dog was inspected, and ticks were carefully removed with forceps. Ticks were classified as dead or alive, attached or unattached, and counted. The personnel who classified and counted the ticks were not aware of the treatment prescribed for each dog.

Statistical analysis

Statistical analysis was performed using the SAS® software package (SAS Institute Inc., Carey, North Carolina, USA, version 9.2). In all statistical calculations, the statistical unit was a single animal. Percentage efficacy against ticks was calculated for each treatment group and each evaluation time in accordance with the Abbott formula:

In the case of a zero number of ticks, the geometric mean number of ticks (xg) was calculated as follows:

where n is the number of animals, i is the index, and xi is the number of ticks on the ith animal.

The significance of differences was evaluated by comparing the logarithm of the number of live ticks in each treated group with the logarithm of the number of ticks in the corresponding control group for each time of assessment.

Treatment groups and control groups were compared using a mixed linear model, in which the group of animals had a fixed effect and the block a random effect. The two-sided confidence level for the F-criteria of the model effects was chosen equal to a = 0.05.

results

In none of the 24 dogs treated with fluralaner, treatment-related adverse events were found during the 12-week period after treatment. The effectiveness of the destruction of ticks was 89.6% after 4 hours, 97.9% after 8 hours and 100% after 12 and 24 hours after treatment.

Eight hours after reinfection, the efficacy was 96.8%, 83.5%, and 45.8% 4, 8, and 12 weeks after infection, respectively. After 12 and 24 hours after repeated infections throughout the entire 12-week study period, the efficiency of tick kill was at least 98.1%.

In dogs receiving fluralaner, the number of ticks at 4, 8, 12, or 24 hours after treatment was significantly lower (p <0.0001) than in control dogs not receiving treatment. In dogs treated with fluralaner, the number of ticks at 8, 12 and 24 hours after re-infection was also significantly lower (at all time points p <0.0001; 8 hours after re-infection at week 12, p <0.004) than in control dogs. 4 hours after re-infection at week 4, a significantly lower number of ticks was also recorded (p <0.03).

The discussion of the results

Fluralaner (Bravecto ™) is the first ectoparasiticide for oral use, showing a significant duration of action against ticks. This study clearly shows that fluralaner quickly destroys ticks with increasing efficiency over time, and the full effect is achieved after 12 hours and lasts for the entire 12-week period of action.

Before transmission, pathogens are activated directly in the salivary glands, or they need a reactivation period for reproduction and migration to the salivary glands. This reactivation period begins after attachment to the host, and transmission occurs when the tick burps excess fluid into the wound from the bite.

Several studies have been conducted to evaluate the time required for transmission of the pathogen. Infected ticks were allowed to feed on the host's body for certain periods of time.

After removing ticks, the host was checked for the presence or absence of a pathogen or specific immune response. If the data indicated that the host was in contact with the pathogen, then the time spent by the tick on the host was considered sufficient to transmit the pathogen.

Transmission to dogs of Babesia canis from infected D. reticulatus ticks occurs no earlier than 48 hours later. Moreover, Prullage et al. concluded that the transmission frequency of B. burgdorferi, A. phagocytophilum and B. microti is significantly reduced if ticks are not allowed to feed for more than 24 hours.

After the transmission becomes possible, the probability of transmission of the pathogen increases significantly and continues to increase with increasing duration of bloodsucking. When comparing data on the time of transmission of pathogens with the results of our study, we can conclude that fluralaner kills ticks before transmission of pathogenic borrelia and babesia begins.

Pathogens such as A. phagocytophilum and E. canis accumulate in the stomach, but they can also be found in the salivary glands, which makes it possible to transmit earlier. Thus, transmission of A. phagocytophilum to mice from nymphs I. scapularis occurs during the first 24 hours, and transmission of E. canis occurs within the first 3-6 hours.

However, these studies were conducted under laboratory conditions; It is not possible to reproduce all available variables of the natural state of the carrier and the host (e.g., invasive pressure from the carrier and the prevalence of infection among carriers, interruption of tick feeding, differences in the age, breed and immune status of the host, as well as the presence of other reservoir hosts) in the laboratory.

More importantly, in some studies on dogs, the use of commercially available acaricidal drugs protected against infection with A. phagocytophilum or E. canis.

According to the description, these drugs have a lower kill rate (i.e., the time required to kill> 90% of attached ticks after treatment / reinfection is longer) than fluralaner. Thus, fluralaner appears to have no less ability to protect dogs from infection with A. phagocytophilum and E. canis.

The systemic mechanism of action of fluralaner provides additional benefits for the user compared with substances intended for local application or used as part of collars and remaining on the surface of the dog’s body.

When using these drugs, a decrease in effectiveness against ticks due to loss of a collar or after bathing is possible. In addition, the fact that ticks die after feeding on a dog receiving fluralaner also reduces the likelihood of infection of another dog, which can occur when using substances with an exceptionally repellent effect.

In addition to the high rate of destruction of parasites and the systemic mechanism of action, the long duration of action of fluralaner brings additional benefits to owners, since it allows less frequent use of the drug compared to other commercially available acaricides for monthly use.

Frequent and regular use of ectoparasiticides is an important tool for the prevention of tick-borne diseases. However, the owners do not observe the regimen well enough, which leads to periods of lack of protection of dogs from ectoparasites, i.e. cases of non-use of funds for monthly use with the recommended frequency.

After application, fluralaner destroys ticks quickly - after 4 hours, and throughout the entire 12-week period of action, it provides an almost complete lethal effect against ticks within 12 hours after infection.

The systemic mechanism of action of fluralaner is an advantage, since it avoids a decrease in efficiency. A 12-week duration of action is an additional advantage, as it overcomes the problem of non-compliance with the repeated treatment regimen.

Due to its rapid acaricidal effect, combined with a long duration of action, fluralaner helps prevent tick-borne diseases.

Tablet for dogs against fleas and ticks MSD "Bravecto" - protection against fleas and ticks up to 12 weeks (review)

In the period from spring to autumn, the invasion of forest ticks creates a lot of trouble not only for people, but also for dogs. Many "dog lovers" are faced with such a disease of dogs as babesiosis or pyroplasmosis.

Without treatment or with late treatment, the disease leads to the death of the dog.Symptoms of the disease: a depressed state of the pet, urine becomes maroon, feces bright yellow, after a few days yellowness of the mucous membranes appears.

Treatment. A chemotherapeutic antiparasitic drug is introduced that kills plasmodia. These drugs are very toxic, but without them it is impossible. Symptomatic treatment is also used. Treatment is quite expensive and does not always give a positive effect. The sooner the owner goes to the doctor, the more chances to save the pet and avoid the unpleasant consequences of the disease.

It is important to prevent the disease! In order to become infected with pyroplasmosis, the tick must sit on the dog and start feeding. Babesia live in the salivary glands of the tick. In order for a tick to sit on a dog, it is not necessary to go to the forest. Ticks are many in the cities. Ticks lay eggs in the ground. Land from the forests is brought into the city by flower beds. A lot of ticks in the Podolsky district of Moscow region.

And every time such a find haunts me for several days. You start to wait and look for the symptoms of this babesiosis. You are in a tense state for several days. This year, a new drug, Bravecto for ticks, appeared. This is a pill that dogs eat themselves.

This drug protects against ticks up to 12 weeks. Compared to drops that guarantee protection for only 4 weeks. I repent, but I sometimes forget to treat dogs and cats every 4 weeks. And here for 12 weeks you can forget about the processing. A systemic drug, that is, it is absorbed into the blood.

This drug can be recommended for dogs living in families with children, since when treating animals with drops, the drug is released onto the skin with sebum, and children constantly pet their pets and then pull their hands in their mouths. By the way, if the dog is often washed or she often bathes in a pond, then protection with drops drops its effectiveness earlier, because we wash off the sebum and the preparation with it from the dog.

In addition, the drops begin to work in about 2 days, and Bravecto tablets in 12 hours. For example, you spontaneously decided to go somewhere in nature, this drug will begin to protect your pet pretty quickly. This medication is compatible with other medications for dogs. Tablets can be used from 2 months of age, but only for dogs weighing more than 2 kg.

If your pet weighs less, then instead of a pill, be sure to treat it with Front Line Spray. I already gave my dogs pills a second time - the first time in April and the second time in July. Ate themselves. I did not notice any side effects (nausea, vomiting, salivation, depression).

The use of tablets does not scare away ticks - Bravecto acts differently - kills a tick in the first 2 hours after a bite and prevents the tick from transmitting the pathogen. During this spring-summer period, she did not remove live ticks from dogs. I found on a small (he has short hair) two dried ticks, that is, they bit him, but then they died.

Ticks with my area (we live in the suburbs, in the village) are much more than last year, that's for sure. I removed 4 ticks from cats during the season (last year it was 1 or 2), I removed one from myself (then I was pretty nervous, waiting for the results of the tick study). I am satisfied with the drug. I recommend to all.

Dali Bravecto. Eczema passed, and they did not have problems with ticks this year - they did not find it.I have never been treated with terrible “side effects” after using the drug. Friends and colleagues gave all their dogs Bravecto too.

All are alive and well. The drug is working. It’s a pity that there is no such drug for cats. A tick can infect a cat with theileriosis, hemobartnellosis, Lyme disease and feline babesiosis. These diseases are very rare. In my practice, this happened for the first time this year. And one of my cats got sick.

P.S. Any antiparasitic drug is poison. No drug gives a 100% guarantee. But if the dog becomes ill with pyroplasmosis and does not receive adequate treatment, she will die and this is already 100%.